{"product_id":"acafrao-curcuma-longa-pimenta-preta-piper-nigrum-500mg-120-capsulas-1","title":"Açafrão (Curcuma longa) + Pimenta Preta (Piper nigrum) | 500mg 120 Cápsulas","description":"\u003cp dir=\"ltr\"\u003e\u003cem\u003e\u003cstrong\u003eFitoterápico, associado ao suporte antioxidante e digestivo. Estudos sugerem que a piperina aumenta a biodisponibilidade da curcumina. Na tradição popular, também é citada no cuidado metabólico e articular.\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003eComposto fitoterápico manipulado , em cápsula gelatinosa, desenvolvido com extrato seco de \u003c\/span\u003e\u003cspan\u003eCúrcuma longa L.\u003c\/span\u003e\u003cspan\u003e (açafrão-da-terra) associado a \u003c\/span\u003e\u003cspan\u003ePiper nigrum L.\u003c\/span\u003e\u003cspan\u003e (pimenta-preta), espécie reconhecida por sua ação bio-potencializadora. A cúrcuma contém naturalmente curcuminoides (curcumina, demetoxicurcumina, bisdemetoxicurcumina), além de óleos voláteis como turmerona e zingibereno. A piperina, alcaloide da pimenta-preta, atua na inibição de enzimas e transportadores envolvidos no metabolismo (UGT, CYP3A4, P-gp), favorecendo maior biodisponibilidade da curcumina e de seus metabólitos.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEstudos científicos sugerem que esta associação pode  aumentar a biodisponibilidade  da curcumina, o que fundamenta sua ampla utilização em suplementos. Pesquisas experimentais relatam efeitos anti-inflamatórios em modelos de obesidade e sinergia antitumoral em linhas celulares, além de possíveis benefícios metabólicos e antioxidantes. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNa tradição popular, a associação entre cúrcuma e pimenta-preta é citada como auxiliar digestivo, de vitalidade e equilíbrio metabólico. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eComposição por dose (1 cápsula\/dose)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCúrcuma longa L.\u003c\/span\u003e\u003cspan\u003e (açafrão-da-terra, rizoma) – 500 mg – extrato seco\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePiper nigrum L.\u003c\/span\u003e\u003cspan\u003e (pimenta-preta, fruto) – 5 mg – extrato seco padronizado em piperina\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eExcipientes: Aerosil, Estearato de Magnésio, Silicato de Magnésio e Microcel\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eApresentação: cápsula gelatinosa\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eRecomendações de uso\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTomar 1 dose, duas vezes ao dia (manhã e noite), antes ou após as refeições, ou conforme orientação de profissional de saúde.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eConservação\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eConservar em temperatura ambiente (15 ºC a 30 ºC), em local seco, protegido da luz e da umidade. Após aberto, manter a embalagem bem fechada.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eInformações importantes \u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAs contraindicações a seguir referem-se à \u003c\/span\u003e\u003cspan\u003eCurcuma (Curcuma longa)\u003c\/span\u003e\u003cspan\u003e:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eContraindicada em casos de obstrução biliar.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eUtilizar com precaução em indivíduos com histórico de doenças gastrointestinais, como úlcera péptica, colite ulcerativa ou Doença de Crohn.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePode potencializar os efeitos de terapias hipolipemiantes (redutoras de lipídios sanguíneos).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eContraindicada em pessoas com histórico de sangramento ou distúrbios hemorrágicos, assim como em usuários de anticoagulantes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDeve ser evitada em casos de úlceras gástricas ativas.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eInformações importantes\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNunca utilize sem orientação de um profissional habilitado.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eImagens meramente ilustrativas.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePessoas com hipersensibilidade à substância ativa não devem ingerir o produto.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEm caso de reação adversa ou hipersensibilidade, recomenda-se descontinuar o uso e consultar o médico ou outro profissional habilitado. .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNão utilize o produto com prazo de validade vencido.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eManter em temperatura ambiente (15 ºC a 30 ºC). Proteger da luz, do calor e da umidade. Nessas condições, o produto se mantém apropriado para o consumo, respeitando sua validade.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTodo produto deve ser mantido fora do alcance de crianças e animais domésticos.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEste produto não deve ser utilizado por mulheres grávidas sem orientação médica ou de outro profissional habilitado.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eO uso durante o período de amamentação também não é recomendado sem orientação médica.ou de outro profissional habilitado.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEste produto não deve ser utilizado por menores de 18 anos sem orientação médica ou de outro profissional habilitado.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSiga corretamente o modo de usar. Não havendo melhora dos sintomas, procure orientação médica.ou de outro profissional habilitado.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA eficácia e os resultados dependem do uso correto da posologia e da dose recomendada por profissional habilitado; considere as diferenças individuais (metabolismo, doenças crônicas, genética). O produto não garante efeitos iguais para todos.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eNão substitui alimentação equilibrada, nem hábitos saudáveis;\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eContém derivados de origem animal (gelatina)\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSE PERSISTIREM OS SINTOMAS, O MÉDICO DEVERÁ SER CONSULTADO.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eDados do produto\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMarca:\u003c\/span\u003e\u003cspan\u003e Knnab\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003eTipo: \u003c\/span\u003e\u003cspan\u003eProduto fitoterápico manipulado \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eForma farmacêutica:\u003c\/span\u003e\u003cspan\u003e Cápsulas gelatinosas.\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003c\/span\u003e\u003cspan\u003eQuantidade:\u003c\/span\u003e\u003cspan\u003e 120 cápsulas\u003c\/span\u003e\u003cspan\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReferências científicas\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eCho HK, Park CG, Lim HB. Construction of a synergistic combination model for turmeric (Curcuma longa L.) and black pepper (Piper nigrum L.) extracts: Enhanced anticancer activity against human lung cancer cells A549 and NCI-H292. \u003c\/span\u003e\u003cspan\u003eCurr Issues Mol Biol\u003c\/span\u003e\u003cspan\u003e. 2024 Jun 1;46(6):5551-5560. doi:10.3390\/cimb46060332. \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38921003\/\"\u003e\u003cspan\u003ePMID: —38921003\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eSetyaningsih D, Santoso YA, Hartini YS, Murti YB, Hinrichs WLJ, Patramurti C. \u003c\/span\u003e\u003cspan\u003eIsocratic high-performance liquid chromatography for simultaneous quantification of curcumin and piperine in a microparticle formulation containing Curcuma longa and Piper nigrum\u003c\/span\u003e\u003cspan\u003e. Heliyon. 2021 Mar;7(3):e06541. doi:10.1016\/j.heliyon.2021.e06541. \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33851044\/\"\u003e\u003cspan\u003ePMID: 33842325;\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e Artigo:\u003c\/span\u003e\u003ca href=\"https:\/\/drive.google.com\/file\/d\/1qPKcPpexRKc6FGCf_3zW6_ZMVDmoOaCc\/view?usp=drive_link\"\u003e\u003cspan data-rich-links='{\"fple-t\":\"Heliyon - curcuma longa and piper nigrum.pdf\",\"fple-u\":\"https:\/\/drive.google.com\/file\/d\/1qPKcPpexRKc6FGCf_3zW6_ZMVDmoOaCc\/view?usp=drive_link\",\"fple-mt\":\"application\/pdf\",\"type\":\"first-party-link\"}'\u003eHeliyon - curcuma longa and piper nigrum.pdf\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eStati G, Rossi F, Sancilio S, Basile M, Di Pietro R. \u003c\/span\u003e\u003cspan\u003eHepatotoxicity of Curcuma longa: An Unfounded Accusation? Cases Assessed for Causality Using the RUCAM Method\u003c\/span\u003e\u003cspan\u003e. Front Pharmacol. 2021 Oct 28;12:780330. doi:10.3389\/fphar.2021.780330. \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34776989\/\"\u003e\u003cspan\u003ePMID: 34777274\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e; \u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003ePrasad S, Aggarwal BB. Cúrcuma, a Especiaria Dourada: Da Medicina Tradicional à Medicina Moderna. Em: Benzie IFF, Wachtel-Galor S, editores. Medicina Herbal: Aspectos Biomoleculares e Clínicos. 2ª edição. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2011. \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92752\/\"\u003e\u003cspan\u003eCapítulo 13. \u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eEl-Saadony MT, Yang T, Korma SA, Sitohy M, Abd El-Mageed TA, Selim S, Al Jaouni SK, Salem HM, Mahmmod Y, Soliman SM, Mo'men SAA, Mosa WFA, El-Wafai NA, Abou-Aly HE, Sitohy B, Abd El-Hack ME, El-Tarabily KA, Saad AM. Impactos da cúrcuma e de seu principal bioativo, a curcumina, na saúde humana: aplicações farmacêuticas, medicinais e alimentares: uma revisão abrangente. \u003c\/span\u003e\u003cspan\u003eFront Nutr\u003c\/span\u003e\u003cspan\u003e. 2023;9:1040259. \u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9881416\/?utm_source=chatgpt.com#abstract1\"\u003e\u003cspan\u003ePMID: 36712505\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eXu Q, Lian H, Zhou R, Gu Z, Wu J, Wu Y, Li Z. \u003c\/span\u003e\u003cspan\u003eCurcumin and multiple health outcomes: a comprehensive critical review of interventional meta-analyses\u003c\/span\u003e\u003cspan\u003e. Front Pharmacol. 2025 Jun 4;16:1601204. doi:\u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3389\/fphar.2025.1601204\"\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e10.3389\/fphar.2025.1601204\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eElgar K. \u003c\/span\u003e\u003cspan\u003eCurcumin: A review of clinical use and efficacy\u003c\/span\u003e\u003cspan\u003e. \u003c\/span\u003e\u003ca href=\"https:\/\/www.nmi.health\/curcumin-a-review-of-clinical-use-and-efficacy\/?utm_source=\"\u003e\u003cspan\u003eNutr Med J. 2022;1(1):10-31.\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e Artigo: \u003c\/span\u003e\u003ca href=\"https:\/\/drive.google.com\/file\/d\/1wr2L9rWKE65G_KM8wGnjDkICZuztrS7H\/view?usp=drive_link\"\u003e\u003cspan data-rich-links='{\"fple-t\":\"NMJ_Curcumin_A-Review-of-Clinical-Use-and-Efficacy-1.pdf\",\"fple-u\":\"https:\/\/drive.google.com\/file\/d\/1wr2L9rWKE65G_KM8wGnjDkICZuztrS7H\/view?usp=drive_link\",\"fple-mt\":\"application\/pdf\",\"type\":\"first-party-link\"}'\u003eNMJ_Curcumin_A-Review-of-Clinical-Use-and-Efficacy-1.pdf\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eKunnumakkara AB, Hegde M, Parama D, Girisa S, Kumar A, Daimary UD, Garodia P, Yenisetti SC, Oommen OV, Aggarwal BB. \u003c\/span\u003e\u003cspan\u003eRole of turmeric and curcumin in the prevention and treatment of chronic diseases: lessons learned from clinical trials\u003c\/span\u003e\u003cspan\u003e. ACS Pharmacol Transl Sci. 2023;6(4):447–518. \u003c\/span\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10111629\/\"\u003e\u003cspan\u003ePMID: 37082752\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e doi: 10.1021\/acsptsci.2c00012\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cb id=\"docs-internal-guid-503d3786-7fff-003b-2db4-14fe5e64cdd4\"\u003e\u003cspan\u003eNeyrinck AM, Alligier M, Memvanga PB, Névraumont E, Larondelle Y, Préat V, Cani PD, Delzenne NM. \u003c\/span\u003e\u003cspan\u003eCurcuma longa extract associated with white pepper decreases diet-induced inflammation in subcutaneous adipose tissue\u003c\/span\u003e\u003cspan\u003e. PLoS One. 2013 Nov 19;8(11):e81252. doi: 10.1371\/journal.pone.0081252. \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24260564\/\"\u003e\u003cspan\u003ePMID: 24260564 \u003c\/span\u003e\u003c\/a\u003e\u003c\/b\u003e\u003c\/p\u003e","brand":"Knnab","offers":[{"title":"Default Title","offer_id":51551947424026,"sku":"KNN.SPL.100008","price":55.5,"currency_code":"BRL","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0754\/0686\/8762\/files\/Knnab-Rotulocapsula-Acafrao_Pimenta-120capsulas.png?v=1768214014","url":"https:\/\/knnab.com.br\/products\/acafrao-curcuma-longa-pimenta-preta-piper-nigrum-500mg-120-capsulas-1","provider":"Knnab","version":"1.0","type":"link"}